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Watch Closely (1)pentobarbital will minimize the level or effect of fentanyl by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead to your lessen in fentanyl plasma concentrations, insufficient efficacy or, possibly, advancement of a withdrawal